My statement is based upon assumption that anyone using larger injectors would already have appropriately calibrated the MAF through the use of a new tube or different transfer function accordingly. Remember, this thread started vague.The higher pressure is necesary to allow the injectors to flow their rated value. This is also vital to proper spray patterns as well according to MSD tech support. The injectors need to be ran at the pressure they are rated at for proper performance. Regardless of the EEC adaptive learning strategy, it does not dial out the additional pressure, it compensates pulsewidth to maintain proper flow. An often overlooked aspect of running higher pressure in the EEC controlled return fuel supply car is its need to have the fuel available on demand. Sure, the computer can and will lean things out if it needs to, however, when the temperature drops 50*+ because winter is coming and oxygen density is higher per given unit of air entering the motor as a result, I would rather have the fuel there upon demand of the computer. Remember LEAN IS MEAN especially on our forced induction motors. A buddy of mine learned this the hard way in his supercharged 80s stang when he didnt spring for an AFPR with the aftermarket injectors. He calculated fuel demand off of 50lb injectors which werent delivering rated flow at stock pressure and lost a piston on the dyno before getting the chance to add fuel.
Of course, a good tune is essential for the most power from your combination, but keeping the balance of parts in check is important as well.