I have been running my car for years at the 10:1 compression, I had the tops of the pistons ceramic coated to deflect the heat away from the piston. Untill last year i ran a 100% stock tune with sunoco ultra 94 pump gas. I was running 12.2 on the pump gas then and at 3,800 pound race weight. i ran NGK 4554 spark plugs which is a pretty cold race plug that is shorter plug than stock and is a non projected tip. Now all of the plug threads are encased by the head to elimate hot spots and cause detonation. I now run the Evans waterless coolant which i think helps alot with my 20+ pounds of boost, which i still run pump gas on the street. That coolant dosen't boil till 375 degrees, which helps elimate air pockets around the cylinder and once again elimates hot spots.